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EFFICACY OF QUININTAS IN PYOMETRA IN BITCHES
Sushovan Roy
Professor & Head
Department of Vet. Clinical Medicine
College of Veterinary Science and A.H.,
Anjora Durg, (C.G.)
Pyometra
is a hormonally mediated diestrual disorder. Progesterone induced
endometrial tryperplasia usually precedes the development of pyometra.
Endometrial thickening is caused by an increase in the size and number
of endometrial glands which may show secretory activity (Nelson and
Feldman, 1986). Bacterial tenia predominantly associated with
pyometra are Escherechia coli (Grindlay et al., 1973). Pyometra is a
disorder of middle aged bitches and it is more common in bithces with
abnormal oestrus cycles and pseudopregnancy (Whitney, 1976).
Ovariohysterectomy is the treatment of choice for pyometra. In those
cases where it is essential to retain reproductive function or where
disease, medical therapy may be considered (Arthur, 2001). The
present study is therefore, taken up to evaluate the efficacy of
Quinintas along with PGF2α and Myron in the treatment of open cervix
pyometra.
Case History,
Clinical Signs and Treatment
Twenty
bitches of different breeds namely Spiz, (10), German Shepherd (6)
Dobermann(2) Boxer (4) Labrador (1) aged 6-10 years with the history
of vaginal discharge was the subject of study. The character of the
vulvar discharge was of thin consistency and light chocolate brown in
colour and had a bad odour. The vulva was generally enlarged and
maximum owners might have considered this to be continuation of
oestrus. The common clinical singsobserved were lethary, depression,
inappetance, polyuria, dehydration, and occasional vomiting. Eight
bitches showed elevated body temperature and rest of the twelve
bitches showed normal body temperature. The condition was diagnosed
as open cervix pyometra on the basis of clinical assessment and
elevated WBC count (20000-30000/mm3).
The
bitches were randomly divided into two groups, each group comprising
of 10 bitches. Bitches of group A were treated with
Lutalyse(aproducte of Unichem Laboratories containing PGF2α ) at the
dose rate of 0.1-0.25mg/kg b.wt. S/C for 5 days and inj. Quinintas ( a
product of Intas Pharmaceuticals Ltd, each ml containing enrofloxacin
100mg). @ 1ml/20kg b.wt. I/M for 5 days. Bitches of group B were
treated with inj. Quinintas at the same dose rate along with a poly
herbal tab Myron ( aproduct of Alarsin, containing Hirabol, Lodhar,
Dhavdi flower, Ardusi, leaves, Ardusi ghan, Raswanti, Bang Bhasma,
kasis, Shailajit, Abhrak Bhasma) @ 1-2 tab twice daily for 2-3 weeks.
In some cases perenteral fluid therapy and antiemetics were given.
The efficacy of therapy was ascertained on the basis of restoration of
leucocyte count and the improvement in the clinical signs.
Result and
Discussion
Following
therapy 8 bitches of group A were completely cured where as the
bitches showed moderate signs of improvement and six bitches of group
B were completely cured. No recurrence of pyometra was reported in
cured cases and four out of eleven cured bitches conceived when mated
subsequently. The bitches that were not cured by therapy were
recommended for ovariohysterectomy.
It was
suggested that Pyometra was the result of excessive and/or prolonged
stimulation of the uterus by progeste4rone from ‘retained’ or
‘Cystic’corpora futea (Hardy and Osborne, 1974). In the present study
the pyometra was reported that mean age of clinical cases was 8.2
years, with only 12% of cases under 6 years of age. A marked
leucocytosis was observed in the suffering bitches. The findings are
in conformity with Roberts (1999). Eight out of the ten bitches of
group A were successfully treated with PGF2 α and Enrofloxacin. E.
coli is a gram negative organism, predominantly associated with
pyometra (Grindlay et al, Loc. cit) and Enrolfloxacin gave good
efficacy against the infection Anjaneyulu et al. (1999) found
Enrofloxacin to be highly effective in bovine endometritis. The
adverse signs of restlessness and anorexia were observed in some of
the cases. Adverse side effects such as vomition, salivation, panting
and restlessness were observed with high dose prostaglandins (Nelson
and Feldman, loc. cit). Davidson (1989) discouraged prostaglandin
therapy in bitches more than 7 years of age. However, Sridevi et al.
(2000) successfully treated canine open cervic pyometra with low dose
prostaglandin without any adverse effects.
The
success of treatment with Myron and Enroflaxacin in the bitches of
group B was 60% rial agent, disinfects and tones up genital and
reproductive tract and helps in eradicating utero –vaginal
mucopurulent discharge. According to Dange (1978), Myron was found
useful in the treatment of resistant and chronic pathologican
conditions of infectious origin and was also found useful is cleaning
and toning up the uterus.
Though
ovariohysterctomy is the treatment of choice for pyometra but the
major drawback is that the ovariohysterectomised bitch cannot be used
for breeding. Bitches that are presented early in the course of the
disease are usually at low surgical risks and success rates up to
93\2% have been reported (Austad, 1952).
References
Anjaneyulu, Y., Wilson, J., and James, R.M. (1999). Antibiogram in
Bovine Endometrits-A field study. Indian Vet. J., 76:351.
Arthur, G.H. (2001). Arthur’s Veterinary reproduction and obsterics. 8th
end. Harcourt Publishers ltd. New Delhi.
Austad, R. (1951). Nord. Vet. Med., 14:67.
Dange, B.N. (1978). Clinical trials wity Myron and Aloes compounds in
case of bovine infertility. Indian Vet. J. 55:657.
Davidson. A.P. (1989). In Kirk,R.W. (Ed):current Veterinary therapy
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Hardy, R.M. and Osborne, G.H. (1974), Current Veterinary therapy small
animal Practice, Ed. Kirk, R.W.W.B. Sunders Co. Philadelphia. P. 1229.
Nelson, R.W. and Feldman, E.C. (1986). Small Animal Practice, 16:561.
Roberts, S.J. (1999). Veterinary obstetrics and Genital diseases (Theriogenology).
IInd Edn. CBS Publishers & Distributors, New Delhi.
Sridevi, P., Balasubramanian, S., Devanathan, I.G. and Pattabiraman,
S.r. (2000). Low dose Prostaglandis F2 Alpha Therapy in treatment of
canine pyometra. Indian Vet. J. 77. 889-890.
Whitney, J.C. (1976). J. Small Anim. Pract., 8:274.
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